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Bus is a popular kind of transport between Vienna and Prague. Bus connections are frequent (several buses every day in both directions) and prices very reasonable. On average, the bus travel from Vienna to Prague takes about 4 hours. You can find detailed information about schedule, prices, discounts, and luggage restrictions on PragPrague.com: Bus from Vienna to Prague.
Book Vienna to Prague bus tickets with Eurolines.
In Vienna the bus to Prague departs from Erdberg Bus Station. Though Erdberg Station is situated outside the Inner City, it is very easy fast to get from the very centre of Vienna to Erdberg by the U-Bahn (metro) line U3.
Here you can search hotels near Erdberg Bus Station in Vienna.
The bus from Vienna arrives at the main international bus station Praha-Florenc in the centre in Prague. Florenc is conveniently located about 10 minutes walk from Prague Old Town and about 15-20 minutes from Old Town Square. It is a busy station for both long-distance and local public transport and has direct connections to virtually all parts of Prague.
Here you can search hotels near Prague Florenc Bus Station.